Ruffle assembly

Across TCGA cell cohorts, RNA activity of the Ruffle assembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM265, NUP54, and MIIP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM265 grouped by Ruffle assembly-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM265 →	+2.242	+1.545	<.001	<.001	3	6
BLOOD_Lymphoma	NUP54 →	-1.144	-1.652	.003	.006	3	5
UPPER_AERODIGESTIVE_TRACT	MIIP →	-0.873	-1.529	<.001	.002	3	5
PANCREAS	CDA →	+2.943	+1.291	.008	.005	3	5
STOMACH	CAST →	+2.036	+2.048	<.001	<.001	3	5
LIVER	PLSCR1 →	+0.716	+1.777	.007	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM265 by Ruffle assembly activity — LARGE_INTESTINE

Explore this box plot interactively →