Ruffle assembly

Across TCGA cell cohorts, RNA activity of the Ruffle assembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL4, EIF2AK1, and ZPR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ruffle assembly activity versus KLHL4 in PANCREAS (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KLHL4 →	+1.518	+0.254	.004	<.001	3	5
SOFT_TISSUE	EIF2AK1 →	+0.697	+0.921	.001	.005	3	4
LUNG_SCLC	ZPR1 →	-0.614	-0.937	.004	.001	3	4
LUNG_SCLC	MSH2 →	-0.794	-0.882	<.001	.001	3	4
URINARY_TRACT	GLTPD2 →	-0.633	-0.281	<.001	.005	3	4
CNS	PTPRK →	+0.864	+0.656	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097178 vs KLHL4 — PANCREAS

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