Mesenchymal stem cell proliferation

pathway activity — cross-omics
GO:0097168Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Mesenchymal stem cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FN1, C8G, and EMILIN1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVFN1 →+0.771+0.064<.001<.00139
HNSCC8G →+0.508+0.067.001.00238
BRCAEMILIN1 →+0.464+0.061.001.00338
CCRCCANGPTL2 →+0.587+0.086<.001<.00138
OVITGA5 →+0.614+0.079<.001.00338
LSCCLGALS1 →+0.600+0.097<.001<.00138
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration