GABAergic neuron differentiation

Across TCGA patient cohorts, RNA activity of the GABAergic neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF3, SHANK3_S1570, and STXBP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GABAergic neuron differentiation activity versus WIPF3 in OV (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WIPF3 →	-0.812	-0.078	<.001	.001	3	6
CCRCC	SHANK3_S1570 →	+0.631	+0.077	.001	<.001	3	5
BRCA	STXBP1 →	+0.336	+0.043	<.001	<.001	3	5
OV	MYADM →	+0.440	+0.068	<.001	<.001	3	5
CCRCC	TIMM44 →	-0.264	-0.061	<.001	<.001	3	5
OV	CD248 →	+0.714	+0.073	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097154 vs WIPF3 — OV

Explore this scatter interactively →