GABAergic neuron differentiation

Across TCGA patient cohorts, RNA activity of the GABAergic neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIPK2B, ADGRL4, and TIE1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GABAergic neuron differentiation activity versus DIPK2B in CCRCC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DIPK2B →	+0.837	+0.381	<.001	<.001	3	8
CCRCC	ADGRL4 →	+0.736	+0.299	<.001	<.001	3	7
CCRCC	TIE1 →	+0.843	+0.369	<.001	<.001	3	7
CCRCC	MYCT1 →	+0.904	+0.350	<.001	<.001	3	6
CCRCC	BCL6B →	+0.815	+0.337	<.001	<.001	3	6
CCRCC	CLEC14A →	+1.050	+0.348	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097154 vs DIPK2B — CCRCC

Explore this scatter interactively →