GABAergic neuron differentiation

Across TCGA cell cohorts, RNA activity of the GABAergic neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V1G1, TPP1, and ATP8B1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP6V1G1 grouped by GABAergic neuron differentiation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ATP6V1G1 →	-0.582	-1.868	.004	<.001	3	4
URINARY_TRACT	TPP1 →	-2.130	-2.326	.002	<.001	3	4
LUNG_SCLC	ATP8B1 →	+2.975	+1.416	.004	.006	3	4
STOMACH	PNMA6A →	-2.187	-1.264	.003	.001	3	4
LUNG_SCLC	NOTCH3 →	-2.417	-1.583	.006	<.001	3	4
PANCREAS	ARF6 →	+0.745	+0.854	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP6V1G1 by GABAergic neuron differentiation activity — URINARY_TRACT

Explore this box plot interactively →