Mesenchymal cell apoptotic process

pathway activity — cross-omics
GO:0097152Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Mesenchymal cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSXP10, HCRTR1, and PTPRM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCSSXP10 →+0.795+0.402.001<.00134
CCRCCHCRTR1 →+0.282+0.244.001.00834
HNSCPTPRM →+0.505+0.253.005.00434
LUADF8 →+0.541+0.405.004.00434
LUADRNA5SP507 →+0.704+0.377.004.00834
HNSCCPVL-AS1 →+0.904+0.298<.001.00534
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration