Gephyrin clustering involved in postsynaptic density assembly

Across TCGA pan-cancer cohorts, RNA activity of the Gephyrin clustering involved in postsynaptic density assembly pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Gephyrin clustering involved in postsynaptic density assembly pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BLCA and SKCM, show the opposite pattern, with higher activity associated with better survival.

BLCA, SKCM, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	IV	0.597	0.378	.001	47	view →
SKCM	DFS	Median	II,III,IV	0.664	0.463	<.001	45	view →
HNSC	OS	Tertile	II,III,IV	0.517	0.315	.003	34	view →
SCLC	OS	Tertile	All	0.813	0.584	.002	31	view →
ESCA	OS	Median	IV	0.698	0.222	.006	25	view →
THYM	OS	Median	All	0.898	1.000	.001	25	view →
PRAD	DFS	Tertile	All	0.827	0.938	<.001	18	view →
CHOL	DFS	Quartile	All	0.072	0.597	.007	16	view →
KIRP	OS	Median	III,IV	0.811	0.506	.002	15	view →
ACC	DFS	Quartile	III,IV	0.083	0.604	<.001	14	view →
UVM	OS	Median	III,IV	0.831	0.381	.022	12	view →
LGG	OS	Tertile	All	0.916	0.843	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0097116–BLCA (DFS)

Open the BLCA breakdown →