AMPA glutamate receptor clustering

Across TCGA patient cohorts, RNA activity of the AMPA glutamate receptor clustering pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOJ, HSPA12B, and DIPK2B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AMPA glutamate receptor clustering activity versus RHOJ in CCRCC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RHOJ →	+0.746	+1.214	<.001	<.001	3	7
OV	HSPA12B →	+0.902	+0.343	<.001	<.001	3	7
CCRCC	DIPK2B →	+0.795	+0.827	<.001	<.001	3	7
CCRCC	TMEM88 →	+1.186	+1.129	<.001	<.001	3	7
CCRCC	MMRN2 →	+0.807	+0.738	<.001	<.001	3	7
OV	SELP →	+0.894	+0.331	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097113 vs RHOJ — CCRCC

Explore this scatter interactively →