AMPA glutamate receptor clustering

Across TCGA cell cohorts, RNA activity of the AMPA glutamate receptor clustering pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGMAT, TTYH2, and HKDC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGMAT grouped by AMPA glutamate receptor clustering-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	AGMAT →	-3.222	-1.334	.001	<.001	3	3
STOMACH	TTYH2 →	+2.298	+1.353	.002	.006	3	3
STOMACH	HKDC1 →	-3.315	-1.082	<.001	<.001	3	3
STOMACH	ALDH18A1 →	-1.020	-1.410	.002	.002	3	3
STOMACH	SYT1 →	+1.525	+0.964	<.001	.003	3	3
SOFT_TISSUE	RAD18 →	-0.879	-1.060	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGMAT by AMPA glutamate receptor clustering activity — STOMACH

Explore this box plot interactively →