Postsynaptic density assembly

Across TCGA patient cohorts, RNA activity of the Postsynaptic density assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_S614, CDH13, and P3H1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic density assembly activity versus MAP1B_S614 in LSCC (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B_S614 →	+0.947	+0.047	.001	<.001	3	5
OV	CDH13 →	+0.446	+0.042	<.001	<.001	3	4
OV	P3H1 →	+0.476	+0.045	.002	.003	3	4
LUAD	SGTB_S77 →	+0.422	+0.072	.002	.004	3	4
LUAD	TLN1_S1641 →	+0.530	+0.073	.002	<.001	3	4
LSCC	COL5A1 →	+0.500	+0.055	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097107 vs MAP1B_S614 — LSCC

Explore this scatter interactively →