Postsynaptic density assembly

Across TCGA cell cohorts, RNA activity of the Postsynaptic density assembly pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASEF, CENPA, and PEPD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RASEF grouped by Postsynaptic density assembly-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RASEF →	+1.108	+0.932	.003	.006	3	5
LIVER	CENPA →	+0.548	+1.458	.005	<.001	3	4
BLOOD_Leukemia	PEPD →	+1.965	+1.568	.001	<.001	3	4
BREAST	TMEM43 →	+0.606	+0.767	.007	.001	3	4
BREAST	PIGW →	+0.551	+0.786	.007	.001	3	4
CNS	FOSL2 →	+1.316	+1.109	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RASEF by Postsynaptic density assembly activity — KIDNEY

Explore this box plot interactively →