Craniofacial suture morphogenesis

Across TCGA patient cohorts, RNA activity of the Craniofacial suture morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AEBP1, FKBP9, and SERPINF1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Craniofacial suture morphogenesis activity versus AEBP1 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AEBP1 →	+0.831	+0.071	<.001	<.001	3	9
LSCC	FKBP9 →	+0.630	+0.090	<.001	<.001	3	9
BRCA	SERPINF1 →	+1.061	+0.079	<.001	<.001	3	9
BRCA	TIMP2 →	+0.778	+0.065	<.001	<.001	3	9
LSCC	GLI3_S445 →	+1.254	+0.155	<.001	<.001	3	9
LSCC	ANTXR1 →	+0.640	+0.095	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097094 vs AEBP1 — BRCA

Explore this scatter interactively →