Craniofacial suture morphogenesis

Across TCGA patient cohorts, RNA activity of the Craniofacial suture morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FMOD, COL6A3, and DACT1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Craniofacial suture morphogenesis activity versus FMOD in BRCA (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FMOD →	+1.125	+0.436	<.001	.004	3	8
OV	COL6A3 →	+1.634	+0.664	<.001	.001	3	7
BRCA	DACT1 →	+1.019	+0.573	<.001	.003	3	7
OV	CCN4 →	+1.250	+0.942	<.001	<.001	3	7
BRCA	MEIS3 →	+1.343	+0.892	<.001	<.001	3	7
BRCA	TGFB3 →	+1.582	+0.798	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097094 vs FMOD — BRCA

Explore this scatter interactively →