Craniofacial suture morphogenesis

Across TCGA cell cohorts, RNA activity of the Craniofacial suture morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGGY, CEP76, and GINS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FGGY grouped by Craniofacial suture morphogenesis-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FGGY →	-1.658	-1.544	.004	.002	3	4
OESOPHAGUS	CEP76 →	+0.555	+1.225	.002	<.001	3	4
KIDNEY	GINS2 →	+0.827	+1.330	.007	<.001	3	3
SKIN	FTO →	+0.515	+1.011	.008	.001	3	3
SKIN	DTL →	+0.436	+0.743	.007	.005	3	3
SKIN	WDR62 →	+0.467	+0.829	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FGGY by Craniofacial suture morphogenesis activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →