Craniofacial suture morphogenesis

Across TCGA cell cohorts, RNA activity of the Craniofacial suture morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL13, PCDHB13, and MTMR9LP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IL13 grouped by Craniofacial suture morphogenesis-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	IL13 →	+0.185	+0.102	.002	.006	3	4
OESOPHAGUS	PCDHB13 →	-0.229	-0.129	<.001	.002	3	4
CNS	MTMR9LP →	+0.342	+0.268	<.001	<.001	3	4
BLOOD_Lymphoma	G2E3 →	+0.352	+0.062	<.001	<.001	3	3
LUNG_NSCLC_LUSC	ARHGDIB →	+0.226	+0.144	.006	.001	3	3
LUNG_NSCLC_LUSC	DGCR8 →	-0.422	-0.192	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IL13 by Craniofacial suture morphogenesis activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →