Vascular associated smooth muscle cell development

Across TCGA patient cohorts, RNA activity of the Vascular associated smooth muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the CESC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFATC4, EDNRA, and COL4A2, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular associated smooth muscle cell development activity versus NFATC4 in CESC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	NFATC4 →	+1.255	+0.074	<.001	<.001	3	31
TGCT	EDNRA →	+2.075	+0.137	<.001	<.001	3	31
CHOL	COL4A2 →	+1.992	+0.068	.005	.005	2	31
SCLC	ENG →	+1.312	+0.188	<.001	<.001	3	29
CHOL	MRC2 →	+2.098	+0.088	<.001	<.001	3	29
CHOL	PDGFRB →	+2.294	+0.093	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097084 vs NFATC4 — CESC

Explore this scatter interactively →