Vascular associated smooth muscle cell development

Across TCGA patient cohorts, RNA activity of the Vascular associated smooth muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FSTL1, AEBP1, and EFEMP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular associated smooth muscle cell development activity versus FSTL1 in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FSTL1 →	+0.634	+0.889	.002	<.001	3	5
UCEC	AEBP1 →	+1.061	+0.978	<.001	<.001	3	5
UCEC	EFEMP2 →	+0.818	+0.745	<.001	.001	3	5
UCEC	COL15A1 →	+0.921	+0.791	.001	.002	3	5
UCEC	NFATC4 →	+0.685	+0.671	.004	.004	3	4
CCRCC	ID3 →	+0.969	+0.922	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097084 vs FSTL1 — UCEC

Explore this scatter interactively →