Ductus arteriosus closure

Across TCGA patient cohorts, RNA activity of the Ductus arteriosus closure pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HPGD, ITGA1, and ILK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ductus arteriosus closure activity versus HPGD in LUAD (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HPGD →	+1.760	+0.243	<.001	<.001	3	7
UCEC	ITGA1 →	+0.698	+0.349	.003	.006	2	7
PDAC	ILK →	+0.295	+0.068	<.001	.004	3	6
CCRCC	RPL12_S38 →	-0.588	-0.543	.001	.006	3	6
LUAD	GPATCH4_S135 →	-0.531	-0.146	.007	.008	3	5
COAD	NCK2 →	+0.239	+0.077	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097070 vs HPGD — LUAD

Explore this scatter interactively →