Ductus arteriosus closure

Across TCGA patient cohorts, RNA activity of the Ductus arteriosus closure pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HPGD, PSMD11, and TRIM25, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ductus arteriosus closure activity versus HPGD in OV (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HPGD →	+2.336	+0.493	.002	.004	3	5
CCRCC	PSMD11 →	-0.328	-0.417	<.001	.004	3	4
LSCC	TRIM25 →	-0.317	-0.374	.008	.007	3	4
LSCC	FLAD1 →	-0.451	-0.628	.006	<.001	3	4
LSCC	HPRT1 →	-0.581	-0.355	<.001	.004	3	4
LSCC	CTPS1 →	-0.441	-0.497	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097070 vs HPGD — OV

Explore this scatter interactively →