Ductus arteriosus closure

Across TCGA cell cohorts, RNA activity of the Ductus arteriosus closure pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HPGD, TFAP2B, and MYOCD, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HPGD grouped by Ductus arteriosus closure-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HPGD →	-0.252	-1.207	<.001	<.001	3	8
OVARY	TFAP2B →	-0.252	-1.216	<.001	.005	2	9
LIVER	MYOCD →	-0.321	-1.386	.007	.007	3	6
OVARY	FOXF1 →	-0.197	-1.207	<.001	<.001	3	5
LUNG_SCLC	TP73 →	-0.305	-1.338	.003	<.001	3	4
LIVER	PPDPF →	+0.376	+1.626	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HPGD by Ductus arteriosus closure activity — BLOOD_Leukemia

Explore this box plot interactively →