Ductus arteriosus closure

Across TCGA cell cohorts, RNA activity of the Ductus arteriosus closure pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STRA6, CCDC33, and HPGD, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ductus arteriosus closure activity versus STRA6 in SKIN (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	STRA6 →	+3.284	+0.992	<.001	<.001	3	16
OESOPHAGUS	CCDC33 →	+2.164	+1.794	<.001	<.001	3	15
URINARY_TRACT	HPGD →	+4.870	+1.667	<.001	<.001	3	13
URINARY_TRACT	ELF3 →	+3.137	+0.979	<.001	.005	3	9
URINARY_TRACT	GBP2 →	+3.071	+1.377	<.001	<.001	3	8
URINARY_TRACT	CTSS →	+2.543	+1.285	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097070 vs STRA6 — SKIN

Explore this scatter interactively →