Cellular response to thyroid hormone stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to thyroid hormone stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTIF, FGFR1, and PPP2CB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTIF grouped by Cellular response to thyroid hormone stimulus-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CTIF →	-0.791	-0.542	.002	<.001	3	4
SOFT_TISSUE	FGFR1 →	-3.496	-1.538	<.001	<.001	3	4
OVARY	PPP2CB →	-0.596	-0.972	.002	.001	3	4
BREAST	STEAP1 →	+1.874	+0.842	.001	<.001	3	4
BLOOD_Myeloma	IPO4 →	-1.105	-0.416	.006	.009	2	5
LUNG_NSCLC_LUAD	MRC2 →	-2.113	-0.466	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTIF by Cellular response to thyroid hormone stimulus activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →