Cellular response to thyroid hormone stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to thyroid hormone stimulus pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCLM, VPS37A, and AKR1C1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to thyroid hormone stimulus activity versus GCLM in KIDNEY (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GCLM →	+1.620	+0.253	<.001	.003	3	7
OVARY	VPS37A →	+0.918	+0.362	.002	.006	3	7
LUNG_NSCLC_LUAD	AKR1C1 →	+5.065	+0.408	<.001	<.001	3	6
BREAST	SDCBP →	+1.229	+0.927	<.001	<.001	3	6
LUNG_NSCLC_LUAD	RDX →	+0.818	+0.278	<.001	.008	3	6
OVARY	SYDE1 →	+1.844	+0.345	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097067 vs GCLM — KIDNEY

Explore this scatter interactively →