Response to thyroid hormone

Across TCGA patient cohorts, RNA activity of the Response to thyroid hormone pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCL8, GPR26, and LINC02198, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to thyroid hormone activity versus CCL8 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCL8 →	+1.216	+0.110	<.001	.003	3	4
GBM	GPR26 →	-0.550	-0.352	.009	.008	3	3
LUAD	LINC02198 →	-0.549	-0.092	.008	.008	3	3
UCEC	COMMD2 →	+0.303	+0.204	.006	.003	3	3
UCEC	COA7 →	+0.373	+0.320	.004	<.001	3	3
UCEC	DIPK2A →	+0.510	+0.206	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097066 vs CCL8 — BRCA

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