Response to thyroid hormone

Across TCGA cell cohorts, RNA activity of the Response to thyroid hormone pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERBB3, TUBB2A, and BSPRY, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ERBB3 grouped by Response to thyroid hormone-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ERBB3 →	+2.808	+0.360	<.001	.005	3	5
BLOOD_Leukemia	TUBB2A →	-2.033	-0.222	.001	.004	3	5
LUNG_SCLC	BSPRY →	+2.515	+0.285	<.001	<.001	3	5
LUNG_NSCLC_LUSC	MPZL2 →	+4.496	+0.295	<.001	.009	3	5
BREAST	SLC40A1 →	+1.717	+0.188	.003	<.001	3	4
BREAST	ZNF652 →	+1.084	+0.194	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ERBB3 by Response to thyroid hormone activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →