Response to thyroid hormone

Across TCGA cell cohorts, RNA activity of the Response to thyroid hormone pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSB, C2orf15, and PANX2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to thyroid hormone activity versus CTSB in BLOOD_Lymphoma (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CTSB →	+2.585	+0.254	.006	<.001	3	7
OESOPHAGUS	C2orf15 →	-1.595	-0.261	<.001	.002	3	7
BREAST	PANX2 →	+1.610	+0.275	.004	.001	3	6
LUNG_NSCLC_LUAD	GCLM →	+1.904	+0.414	<.001	<.001	3	6
BLOOD_Leukemia	SRXN1 →	+2.221	+0.201	.001	<.001	3	6
LUNG_NSCLC_LUSC	DLG3 →	-1.910	-0.353	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097066 vs CTSB — BLOOD_Lymphoma

Explore this scatter interactively →