Obsolete ncRNA export from nucleus

pathway activity — cross-omics
GO:0097064Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Obsolete ncRNA export from nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BRD3, NCBP3, and STIM1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMBRD3 →+0.281+0.039<.001<.00138
LSCCNCBP3 →+0.243+0.043.003.00637
CCRCCSTIM1 →-0.215-0.031.008.00537
PDACRER1_S95 →-0.630-0.047.001<.00136
HNSCPSIP1 →+0.578+0.062<.001.00136
BRCAEEF2_S502 →-0.819-0.031<.001.00836
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration