Dendritic spine maintenance

Across TCGA patient cohorts, RNA activity of the Dendritic spine maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ILK, SNX9, and RSU1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendritic spine maintenance activity versus ILK in OV (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ILK →	+0.436	+0.071	<.001	<.001	3	9
OV	SNX9 →	+0.460	+0.068	<.001	<.001	3	8
BRCA	RSU1 →	+0.347	+0.042	<.001	<.001	3	8
BRCA	FERMT2 →	+0.559	+0.066	<.001	<.001	3	8
OV	PALLD →	+0.779	+0.061	<.001	<.001	3	8
LSCC	PRKG1 →	+0.505	+0.064	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097062 vs ILK — OV

Explore this scatter interactively →