Dendritic spine maintenance

Across TCGA patient cohorts, RNA activity of the Dendritic spine maintenance pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTTN, ATP2A3, and OR7E38P, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendritic spine maintenance activity versus CTTN in LSCC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CTTN →	+0.957	+0.258	.002	.002	3	5
LUAD	ATP2A3 →	-0.783	-0.201	.002	.004	3	3
BRCA	OR7E38P →	+0.515	+0.430	<.001	.001	3	3
BRCA	ST13P10 →	+0.475	+0.353	<.001	.005	3	3
BRCA	TRO →	+0.681	+0.467	.007	<.001	3	3
LUAD	CCDC69 →	-0.412	-0.160	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097062 vs CTTN — LSCC

Explore this scatter interactively →