Dendritic spine maintenance

Across TCGA cell cohorts, RNA activity of the Dendritic spine maintenance pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRAS, IL17D, and KRT15, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendritic spine maintenance activity versus RRAS in BREAST (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RRAS →	+2.024	+0.979	.003	.002	3	6
BLOOD_Lymphoma	IL17D →	-1.790	-1.628	.002	<.001	3	6
OESOPHAGUS	KRT15 →	+3.066	+0.320	<.001	<.001	3	6
LIVER	ITGA3 →	+5.570	+0.472	.006	.005	3	6
UPPER_AERODIGESTIVE_TRACT	ATP5PF →	-1.214	-0.319	.005	.005	3	5
BREAST	IGFBP6 →	+3.417	+0.967	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097062 vs RRAS — BREAST

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