Dendritic cell apoptotic process

pathway activity — cross-omics
GO:0097048Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Dendritic cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-DQB1-AS1, DTHD1, and MS4A4E, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCHLA-DQB1-AS1 →+1.072+0.492<.001.00826
UCECDTHD1 →+1.203+0.563<.001<.00135
HNSCMS4A4E →+0.662+0.573.001<.00135
HNSCRNU4-62P →+1.115+0.504<.001<.00135
LSCCLINC00710 →+0.580+0.614<.001.00435
HNSCMEF2C →+0.850+0.385<.001.00235
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration