Protein linear polyubiquitination

Across TCGA patient cohorts, RNA activity of the Protein linear polyubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC1, COPRS, and HRH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein linear polyubiquitination activity versus TTC1 in PDAC (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TTC1 →	+0.170	+0.443	.004	.001	3	3
PDAC	COPRS →	+0.197	+0.523	.008	.002	3	3
PDAC	HRH1 →	+0.480	+0.665	<.001	<.001	3	3
PDAC	GPN1 →	+0.294	+0.563	<.001	.001	3	3
PDAC	SNORA47 →	-0.553	-0.471	<.001	.005	3	3
OV	PDHX →	-0.365	-0.582	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097039 vs TTC1 — PDAC

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