Regulation of membrane lipid distribution

Across TCGA patient cohorts, RNA activity of the Regulation of membrane lipid distribution pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMHD1, SEPTIN1_S315, and DOCK10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane lipid distribution activity versus SAMHD1 in GBM (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SAMHD1 →	+0.503	+0.055	<.001	<.001	3	7
LSCC	SEPTIN1_S315 →	+0.857	+0.044	<.001	<.001	3	7
LSCC	DOCK10 →	+0.346	+0.047	<.001	<.001	3	7
GBM	ABI3 →	+0.494	+0.047	<.001	<.001	3	7
GBM	IKZF1_S63 →	+0.869	+0.055	<.001	<.001	3	7
LSCC	CAB39 →	+0.364	+0.049	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097035 vs SAMHD1 — GBM

Explore this scatter interactively →