Regulation of membrane lipid distribution

Across TCGA patient cohorts, RNA activity of the Regulation of membrane lipid distribution pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOX1, NEFM, and MAL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane lipid distribution activity versus NOX1 in COAD (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NOX1 →	-1.098	-1.059	.002	<.001	3	3
GBM	NEFM →	+1.048	+0.414	<.001	.001	3	3
GBM	MAL2 →	+0.498	+0.257	.002	.005	3	3
GBM	GLT1D1 →	+0.541	+0.296	.003	.001	3	3
GBM	LINC01792 →	+0.569	+0.382	<.001	.002	3	3
UCEC	ARL2-SNX15 →	+0.155	+0.510	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097035 vs NOX1 — COAD

Explore this scatter interactively →