Regulation of membrane lipid distribution

Across TCGA cell cohorts, RNA activity of the Regulation of membrane lipid distribution pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM8A1, PRKCD, and RAB21, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM8A1 grouped by Regulation of membrane lipid distribution-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM8A1 →	-0.169	-1.128	.001	.004	3	5
BREAST	PRKCD →	-0.105	-0.568	.007	.006	3	5
SOFT_TISSUE	RAB21 →	-0.278	-1.270	.006	<.001	3	5
LIVER	TLN1 →	+0.655	+1.102	.005	.009	2	6
PANCREAS	ANKH →	-0.236	-1.133	.002	<.001	3	5
SKIN	ITGAV →	+0.710	+1.148	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM8A1 by Regulation of membrane lipid distribution activity — LUNG_SCLC

Explore this box plot interactively →