Regulation of membrane lipid distribution

Across TCGA cell cohorts, RNA activity of the Regulation of membrane lipid distribution pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPOCD1, SLFN11, and RPS6KA4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPOCD1 grouped by Regulation of membrane lipid distribution-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPOCD1 →	-0.957	-0.743	.009	.002	2	6
LUNG_NSCLC_LUSC	SLFN11 →	+3.450	+1.341	<.001	.003	3	4
LIVER	RPS6KA4 →	-1.516	-1.472	.007	.005	3	4
LIVER	EIF2AK2 →	-1.218	-1.747	.001	<.001	3	4
BLOOD_Myeloma	BUD31 →	-1.086	-1.288	.006	.002	3	4
BLOOD_Myeloma	BCL7B →	-0.827	-1.324	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPOCD1 by Regulation of membrane lipid distribution activity — LARGE_INTESTINE

Explore this box plot interactively →