Regulation of membrane lipid distribution

Across TCGA cell cohorts, RNA activity of the Regulation of membrane lipid distribution pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HERPUD1, PPP2CA, and MAGEB2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HERPUD1 grouped by Regulation of membrane lipid distribution-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HERPUD1 →	-0.178	-1.250	<.001	<.001	3	3
BONE	PPP2CA →	-0.529	-0.114	.004	.002	3	3
SKIN	MAGEB2 →	+0.138	+0.935	<.001	.001	3	2
LARGE_INTESTINE	SYT3 →	+0.207	+1.007	.002	.002	3	2
LARGE_INTESTINE	SLC6A14 →	+0.170	+1.032	.005	.001	3	2
LARGE_INTESTINE	NEDD4L →	+0.159	+0.798	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HERPUD1 by Regulation of membrane lipid distribution activity — SKIN

Explore this box plot interactively →