Mature conventional dendritic cell differentiation

Across TCGA patient cohorts, RNA activity of the Mature conventional dendritic cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSS, KLHL6, and LILRB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mature conventional dendritic cell differentiation activity versus CTSS in UCEC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CTSS →	+0.956	+0.354	<.001	.002	3	4
UCEC	KLHL6 →	+0.537	+0.286	.004	.004	3	4
BRCA	LILRB1 →	+1.013	+0.275	<.001	<.001	3	4
LSCC	LINC00528 →	+0.417	+0.316	<.001	<.001	3	4
UCEC	VNN2 →	+0.689	+0.293	.004	.004	3	3
UCEC	IRAG2 →	+0.798	+0.500	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097029 vs CTSS — UCEC

Explore this scatter interactively →