Mature conventional dendritic cell differentiation

Across TCGA cell cohorts, RNA activity of the Mature conventional dendritic cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTK1, WRAP73, and SLC5A6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GSTK1 grouped by Mature conventional dendritic cell differentiation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GSTK1 →	-1.334	-0.446	<.001	<.001	3	4
SKIN	WRAP73 →	+0.518	+0.358	<.001	.005	3	3
OVARY	SLC5A6 →	+0.845	+0.799	.004	.008	2	4
LUNG_SCLC	PIGW →	+0.549	+0.410	.008	<.001	3	3
OESOPHAGUS	MSRB3 →	+2.176	+0.368	.001	.005	3	3
LARGE_INTESTINE	ACO2 →	-0.813	-0.254	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSTK1 by Mature conventional dendritic cell differentiation activity — LUNG_SCLC

Explore this box plot interactively →