Dendritic cell differentiation

Across TCGA patient cohorts, RNA activity of the Dendritic cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCAF11, CYTIP, and ADGRE2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendritic cell differentiation activity versus DCAF11 in CCRCC (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DCAF11 →	-0.342	-0.746	<.001	.001	3	6
GBM	CYTIP →	+0.680	+0.644	<.001	<.001	3	6
GBM	ADGRE2 →	+1.139	+0.946	<.001	<.001	3	5
CCRCC	GPR65 →	+0.697	+0.683	<.001	<.001	3	5
GBM	C1orf162 →	+0.937	+0.669	<.001	.002	3	5
GBM	CD53 →	+0.847	+0.646	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097028 vs DCAF11 — CCRCC

Explore this scatter interactively →