Dendritic cell differentiation

Across TCGA cell cohorts, RNA activity of the Dendritic cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL7A1, SLC20A1, and MTCH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendritic cell differentiation activity versus COL7A1 in BLOOD_Lymphoma (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	COL7A1 →	+2.471	+1.243	.004	.006	3	5
SOFT_TISSUE	SLC20A1 →	+1.850	+2.125	.003	<.001	3	4
KIDNEY	MTCH1 →	+1.143	+2.144	.001	<.001	3	4
BLOOD_Lymphoma	MAPKAPK3 →	+1.693	+1.649	.001	<.001	3	4
BLOOD_Lymphoma	SNX22 →	-3.017	-1.309	<.001	.003	3	4
BLOOD_Leukemia	TRIM36 →	+1.740	+1.112	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097028 vs COL7A1 — BLOOD_Lymphoma

Explore this scatter interactively →