Lymphocyte migration into lymphoid organs

Across TCGA patient cohorts, RNA activity of the Lymphocyte migration into lymphoid organs pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRY, MYOF, and DSTNP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte migration into lymphoid organs activity versus FRY in HNSC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FRY →	-0.674	-0.817	.009	.005	2	5
PDAC	MYOF →	+0.557	+0.281	.003	.001	3	4
CCRCC	DSTNP2 →	+0.367	+0.862	<.001	.006	3	4
LUAD	SNX21 →	+0.982	+1.107	<.001	<.001	3	3
LUAD	SESN2 →	+0.498	+0.877	<.001	<.001	3	3
PDAC	RUNX1 →	+0.509	+0.260	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097021 vs FRY — HNSC

Explore this scatter interactively →