Lymphocyte migration into lymphoid organs

Across TCGA patient cohorts, RNA activity of the Lymphocyte migration into lymphoid organs pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WNK1, WNK1_S2027, and WNK1_S2279, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte migration into lymphoid organs activity versus WNK1 in HNSC (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	WNK1 →	+0.380	+1.073	<.001	<.001	3	5
HNSC	WNK1_S2027 →	+0.545	+0.925	<.001	.002	3	5
HNSC	WNK1_S2279 →	+0.545	+0.925	<.001	.002	3	5
HNSC	WNK1_S174 →	+0.503	+1.151	<.001	<.001	3	4
BRCA	TSPAN1 →	-0.899	-0.615	<.001	<.001	3	3
OV	MED14_S1112 →	+0.973	+1.072	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097021 vs WNK1 — HNSC

Explore this scatter interactively →