Lymphocyte migration into lymphoid organs

Across TCGA cell cohorts, RNA activity of the Lymphocyte migration into lymphoid organs pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GJC1, KLHL5, and CREB3L4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GJC1 grouped by Lymphocyte migration into lymphoid organs-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GJC1 →	-2.320	-0.609	.001	.005	3	5
BLOOD_Myeloma	KLHL5 →	-2.126	-1.692	.005	.002	3	4
BLOOD_Myeloma	CREB3L4 →	+1.697	+2.136	<.001	<.001	3	4
BLOOD_Myeloma	LUZP1 →	-0.843	-1.479	.007	<.001	3	4
LARGE_INTESTINE	RSC1A1 →	-0.745	-0.713	.003	.002	3	4
OESOPHAGUS	SRRM1 →	-0.781	-1.393	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GJC1 by Lymphocyte migration into lymphoid organs activity — LARGE_INTESTINE

Explore this box plot interactively →