Renal albumin absorption

pathway activity — cross-omics
GO:0097018Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Renal albumin absorption pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUNX1T1, SRPX, and KANK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCARUNX1T1 →+0.439+0.294.006.00436
UCECSRPX →+0.937+0.633.001.00135
UCECKANK2 →+0.737+0.595.001.00635
UCECFHL1 →+1.597+0.870<.001<.00135
BRCAGAS6 →+1.011+0.414<.001.00535
UCECMYL9 →+1.192+0.695<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration