Renal protein absorption

Across TCGA patient cohorts, RNA activity of the Renal protein absorption pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JPH2, MFAP5, and SYDE1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal protein absorption activity versus JPH2 in UCEC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JPH2 →	+1.001	+0.580	<.001	.002	3	6
BRCA	MFAP5 →	+1.290	+0.767	<.001	<.001	3	6
BRCA	SYDE1 →	+0.756	+0.535	<.001	<.001	3	5
BRCA	PLPP4 →	+0.974	+0.552	<.001	<.001	3	5
BRCA	SSPN →	+0.881	+0.620	<.001	<.001	3	5
OV	PGF →	+0.439	+0.588	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097017 vs JPH2 — UCEC

Explore this scatter interactively →