Response to granulocyte macrophage colony-stimulating factor

Across TCGA patient cohorts, RNA activity of the Response to granulocyte macrophage colony-stimulating factor pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GEMIN5, RPL7A, and HDHD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to granulocyte macrophage colony-stimulating factor activity versus GEMIN5 in CCRCC (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GEMIN5 →	-0.173	-0.047	.001	<.001	3	5
OV	RPL7A →	-0.288	-0.061	.001	.009	3	4
COAD	HDHD3 →	+0.238	+0.031	.004	.003	3	4
UCEC	DDX21_S89 →	-0.594	-0.066	.003	.009	3	4
UCEC	IL33 →	+0.628	+0.075	.002	.003	3	4
UCEC	IRS1_S330 →	+0.565	+0.075	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097012 vs GEMIN5 — CCRCC

Explore this scatter interactively →