Response to granulocyte macrophage colony-stimulating factor

Across TCGA patient cohorts, RNA activity of the Response to granulocyte macrophage colony-stimulating factor pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAFF, ZFP36, and CSRNP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to granulocyte macrophage colony-stimulating factor activity versus MAFF in HNSC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MAFF →	+0.494	+0.629	<.001	<.001	3	5
BRCA	ZFP36 →	+0.995	+0.520	<.001	.002	3	4
LSCC	CSRNP1 →	+0.708	+0.743	<.001	<.001	3	4
LSCC	CXCL2 →	+1.295	+0.550	<.001	<.001	3	4
PDAC	EGR2 →	+0.628	+0.454	.001	.004	3	4
LSCC	MMP19 →	+0.768	+0.655	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097012 vs MAFF — HNSC

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