Response to granulocyte macrophage colony-stimulating factor

Across TCGA patient cohorts, RNA activity of the Response to granulocyte macrophage colony-stimulating factor pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZFP36_S60, RBM7_S204, and REXO1_S914, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to granulocyte macrophage colony-stimulating factor activity versus ZFP36_S60 in HNSC (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZFP36_S60 →	+0.709	+0.940	.001	.002	2	6
OV	RBM7_S204 →	+0.459	+0.451	.002	<.001	3	3
LSCC	REXO1_S914 →	-0.291	-0.633	.001	<.001	3	2
LSCC	SRRM1_S638 →	-0.508	-0.743	<.001	<.001	3	2
UCEC	SUGP2_S224 →	-0.551	-0.644	.001	.001	3	2
LSCC	TNS1_S1505 →	+0.275	+0.772	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097012 vs ZFP36_S60 — HNSC

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